Butyrate producers,“The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics
Gut-microbial butyrate is a short-chain fatty acid (SCFA) of significant physiological
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …
importance than the other major SCFAs (acetate and propionate). Most butyrate producers …
Portrait of the PI3K/AKT pathway in colorectal cancer
SA Danielsen, PW Eide, A Nesbakken, T Guren… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …
Mechanism of apoptosis induced by curcumin in colorectal cancer
Colorectal cancer (CRC) is among the top three cancer with higher incident and mortality
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
rate worldwide. It is estimated that about over than 1.1 million of death and 2.2 million new …
Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers
Changes in plasma and fecal metabolomes in colorectal cancer (CRC) progression (normal-
adenoma-CRC) remain unclear. Here, plasma and fecal samples were collected from four …
adenoma-CRC) remain unclear. Here, plasma and fecal samples were collected from four …
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis
MT Morris, A Jain, B Sun, V Kurbatov, E Muca, Z Zeng… - Cancer Letters, 2023 - Elsevier
There are well demonstrated differences in tumor cell metabolism between right sided
(RCC) and left sided (LCC) colon cancer, which could underlie the robust differences …
(RCC) and left sided (LCC) colon cancer, which could underlie the robust differences …
New insights into bile acids related signaling pathways in the onset of colorectal cancer
Colorectal cancer (CRC) ranks as the second among the causes of tumor death worldwide,
with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate …
with an estimation of 1.9 million new cases in 2020 and more than 900,000 deaths. This rate …
Recent advances in targeted drug delivery systems for resistant colorectal cancer
Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and
morality rate are rising and poses an important threat to the public health. It is known that …
morality rate are rising and poses an important threat to the public health. It is known that …
Cryptotanshinone inhibits the growth and invasion of colon cancer by suppressing inflammation and tumor angiogenesis through modulating MMP/TIMP system, PI3K …
L Zhang, C Chen, J Duanmu, Y Wu, J Tao… - International …, 2018 - Elsevier
The aim of this study was to evaluate the pharmacological effects of CPT on CT26 colon
cancer cells in vivo and in vitro, and to reveal the potential mechanism. CPT suppressed the …
cancer cells in vivo and in vitro, and to reveal the potential mechanism. CPT suppressed the …
[HTML][HTML] To investigate the occurrence and development of colorectal cancer based on the PI3K/AKT/mTOR signaling pathway
J Zhong, S Ding, X Zhang, W Di, X Wang… - Frontiers in Bioscience …, 2023 - imrpress.com
Colorectal cancer (CRC) is the most common malignancy of the gastrointestinal, however,
the underlying mechanisms of CRC remain largely unknown. New evidence suggests that …
the underlying mechanisms of CRC remain largely unknown. New evidence suggests that …
miR-342-3p suppresses hepatocellular carcinoma proliferation through inhibition of IGF-1R-mediated Warburg effect
W Liu, L Kang, J Han, Y Wang, C Shen… - OncoTargets and …, 2018 - Taylor & Francis
Background Insulin-like growth factor-1 receptor (IGF-1R) is a well-studied oncogenic factor
that promotes cell proliferation and energy metabolism and is overexpressed in numerous …
that promotes cell proliferation and energy metabolism and is overexpressed in numerous …