Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

Evading persistent drug resistance in cancer and bacteria is quintessential to restore health
in humans, and impels intervention strategies. A distinct property of the cancer phenotype is …

Osteosarcoma is a common primary malignant bone tumor, the cure rate of which has
stagnated over the past 25–30 years. Arsenic sulfide (As 2 S 2), the main active ingredient of …

Cystathionine β-synthase (CBS) is responsible for the first enzymatic reaction in the
transsulfuration pathway of sulfur amino acids. The molecular function and mechanism of …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

Altered redox status in cancer cells has been linked to lipid peroxidation induced by reactive
oxygen species (ROS) and subsequent formation of reactive lipid electrophiles, especially 4 …

Background Non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths
primarily due to chemoresistance. Somatic mutation of TP5 3 (36%) and epidermal growth …

Significance: It has been proposed that cancer cells are heavily dependent on their
antioxidant defenses for survival and growth. Peroxiredoxins are a family of abundant thiol …

Reactive oxygen species (ROS) are produced predominantly by the mitochondrial electron
transport chain and by NADPH oxidases in peroxisomes and in the endoplasmic reticulum …

Simple Summary Reactive oxygen species (ROS) are unstable derivatives of oxygen that
are generated naturally as products or biproducts of biological reactions. ROS, such as …