Current studies related to lipid identification and determination, or lipidomics in biological
samples, are one of the most important issues in modern bioanalytical chemistry. There are …

Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic communication by
converting chemical signals into an electrical response. Recently solved agonist-bound and …

Ethanol alters nerve signalling by interacting with proteins in the central nervous system,
particularly pentameric ligand-gated ion channels. A recent series of mutagenesis …

Type A γ-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion
channels in the brain. Many anesthetics and neurosteroids act through binding to the …

The superfamily of pentameric ligand-gated ion channels (pLGICs) comprises key players in
electrochemical signal transduction across evolution, including historic model systems for …

Synaptic receptors respond to neurotransmitters by opening an ion channel across the post-
synaptic membrane to elicit a cellular response. Here we use recent Torpedo acetylcholine …

Mycoplasma genitalium is an obligate intracellular bacterium that is responsible for several
sexually transmitted infections, including non-gonococcal urethritis in men and several …

The α7 nicotinic acetylcholine receptor (nAChR), assembled as homomeric pentameric
ligand-gated ion channels, is one of the most abundant nAChR subtypes in the brain …

Membrane proteins are one of the most challenging and attractive objects in modern
structural biology, as they are targets for the majority of medicines. However, studies of …

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion
channels (pLGICs) are not fully understood. Using 19 F nuclear magnetic resonance and …