Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
DICER1 Syndrome: DICER1 Mutations in Rare Cancers
JC Robertson, CL Jorcyk, JT Oxford - Cancers, 2018 - mdpi.com
DICER1 syndrome is a rare genetic disorder that predisposes individuals to multiple cancer
types. Through mutations of the gene encoding the endoribonuclease, Dicer, DICER1 …
types. Through mutations of the gene encoding the endoribonuclease, Dicer, DICER1 …
Ten years of DICER1 mutations: Provenance, distribution, and associated phenotypes
L de Kock, MK Wu, WD Foulkes - Human Mutation, 2019 - Wiley Online Library
DICER1 syndrome is a pleiotropic tumor predisposition syndrome characterized by a
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry
Background Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
Protective effects of epigallocatechin gallate (EGCG) on endometrial, breast, and ovarian cancers
Green tea and its major bioactive component,(−)-epigallocatechin gallate (EGCG), possess
diverse biological properties, particularly antiproliferation, antimetastasis, and apoptosis …
diverse biological properties, particularly antiproliferation, antimetastasis, and apoptosis …
[HTML][HTML] Expanding the spectrum of dicer1-associated sarcomas
M Warren, MC Hiemenz, R Schmidt, J Shows, J Cotter… - Modern Pathology, 2020 - Elsevier
DICER1 syndrome is a hereditary cancer predisposition syndrome caused by deleterious
germline DICER1 mutations. Characteristic “hotspot” somatic mutations of DICER1 have …
germline DICER1 mutations. Characteristic “hotspot” somatic mutations of DICER1 have …
Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup
Embryonal rhabdomyosarcoma (ERMS) of the uterus has recently been shown to frequently
harbor DICER1 mutations. Interestingly, only rare cases of extrauterine DICER1-associated …
harbor DICER1 mutations. Interestingly, only rare cases of extrauterine DICER1-associated …
DICER1‐associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: pathology, molecular genetics, and indications for molecular testing
M Apellaniz‐Ruiz, WG McCluggage… - Genes …, 2021 - Wiley Online Library
Gynecologic sarcomas are uncommon neoplasms, the majority occurring in the uterus. Due
to the diverse nature of these, the description of “new” morphological types and the rarity of …
to the diverse nature of these, the description of “new” morphological types and the rarity of …
[HTML][HTML] Significantly greater prevalence of DICER1 alterations in uterine embryonal rhabdomyosarcoma compared to adenosarcoma
L de Kock, JY Yoon, M Apellaniz-Ruiz, D Pelletier… - Modern Pathology, 2020 - Elsevier
Embryonal rhabdomyosarcomas (ERMS) account for 2–3% of cancers in pediatric and
adolescent populations. They are rarer in adults. We and others have reported that ERMS …
adolescent populations. They are rarer in adults. We and others have reported that ERMS …
DICER1 RNase IIIb domain mutations trigger widespread miRNA dysregulation and MAPK activation in pediatric thyroid cancer
JC Ricarte-Filho, V Casado-Medrano… - Frontiers in …, 2023 - frontiersin.org
DICER1 is a highly conserved RNase III endoribonuclease essential for the biogenesis of
single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic …
single-stranded mature microRNAs (miRNAs) from stem-loop precursor miRNAs. Somatic …