1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …

Lipid droplets (LDs) contribute to key pathways important for the physiology and
pathophysiology of cells. In a homeostatic view, LDs regulate the storage of neutral lipids …

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic
outcomes, independent of overall adiposity. To increase our understanding of the genetic …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Phospholipases A2 (PLA2s) are esterases that hydrolyze the sn-2 ester of
glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes …

Abstract Phospholipase A 2 (PLA 2) enzymes are the upstream regulators of the eicosanoid
pathway liberating free arachidonic acid from the sn-2 position of membrane phospholipids …

Abstract Phospholipase A2 (PLA2) catalyses the hydrolysis of the sn-2 position of
glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 …

Snake venom phospholipases A2 (PLA2) show a remarkable functional diversity. Among
their toxic activities, some display the ability to cause rapid necrosis of skeletal muscle fibers …

Reactive oxygen species are known to contribute to tissue damage during injury and
inflammation. However, these species can also be sensed by the cells and trigger …

Macrophages can be activated through TLRs for a variety of innate immune responses. In
contrast with the wealth of data existing on TLR-dependent gene expression and resultant …