Actinobacteria are one of the most important and efficient groups of natural metabolite
producers. The genus Streptomyces have been recognized as prolific producers of useful …

Background Pharmacological interactions are useful for understanding ligand binding
mechanisms of a therapeutic target. These interactions are often inferred from a set of active …

ABSTRACT The coronavirus (CoV) disease 2019 (COVID-19) pandemic caused by severe
acute respiratory syndrome CoV-2 (SARS-CoV-2) is a health threat worldwide. Viral main …

Cyclic-di-GMP [bis-(3′-5′)-cyclic diguanosine monophosphate] controls a wide range of
functions in eubacteria, yet little is known about the underlying regulatory mechanisms. In …

Six new indole alkaloids including five new glyantrypine derivatives (1, 2a, 2b, 3, 4) and a
new pyrazinoquinazoline derivative (5), together with eight known alkaloids (6–13), were …

The emergence of highly pathogenic influenza A virus strains, such as the new H1N1 swine
influenza (novel influenza), represents a serious threat to global human health. During our …

A water-soluble polysaccharide from Monostroma nitidum, designated MWS, was isolated
using water extraction, anion-exchange and size-exclusion chromatography. MWS was a …

Influenza is a disease for deeply affecting millions of people every year. Recently, there has
been considerable concern regarding the highly pathogenic H5N1 avian influenza virus …

Carrageenan polysaccharide has been reported to be able to inhibit the infection and
replication of many different kinds of viruses. Here, we demonstrated that a 2kDa κ …

Dendrobine, a major component of Dendrobium nobile, increasingly draws attention for its
wide applications in health care. Here we explore potential effects of dendrobine against …