Insights into the assembly and regulation of the bacterial divisome

TA Cameron, W Margolin - Nature Reviews Microbiology, 2024 - nature.com
The ability to split one cell into two is fundamental to all life, and many bacteria can
accomplish this feat several times per hour with high accuracy. Most bacteria call on an …

Splitsville: structural and functional insights into the dynamic bacterial Z ring

DP Haeusser, W Margolin - Nature Reviews Microbiology, 2016 - nature.com
Bacteria must divide to increase in number and colonize their niche. Binary fission is the
most widespread means of bacterial cell division, but even this relatively simple mechanism …

Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division

AW Bisson-Filho, YP Hsu, GR Squyres, E Kuru, F Wu… - Science, 2017 - science.org
The mechanism by which bacteria divide is not well understood. Cell division is mediated by
filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to …

At the heart of bacterial cytokinesis: the Z ring

S Du, J Lutkenhaus - Trends in microbiology, 2019 - cell.com
Bacterial cell division is mediated by the divisome which is organized by the Z ring, a
cytoskeletal element formed by the polymerization of the tubulin homologue FtsZ. Despite …

Insights into the structure, function, and dynamics of the bacterial cytokinetic FtsZ-ring

R McQuillen, J Xiao - Annual Review of Biophysics, 2020 - annualreviews.org
The FtsZ protein is a highly conserved bacterial tubulin homolog. In vivo, the functional form
of FtsZ is the polymeric, ring-like structure (Z-ring) assembled at the future division site …

Bacillus subtilis cell diameter is determined by the opposing actions of two distinct cell wall synthetic systems

MF Dion, M Kapoor, Y Sun, S Wilson, J Ryan… - Nature …, 2019 - nature.com
Rod-shaped bacteria grow by adding material into their cell wall via the action of two
spatially distinct enzymatic systems: the Rod complex moves around the cell circumference …

Shaping an Endospore: Architectural Transformations During Bacillus subtilis Sporulation

K Khanna, J Lopez-Garrido… - Annual review of …, 2020 - annualreviews.org
Endospore formation in Bacillus subtilis provides an ideal model system for studying
development in bacteria. Sporulation studies have contributed a wealth of information about …

Targeting the bacterial division protein FtsZ

KA Hurley, TMA Santos, GM Nepomuceno… - Journal of medicinal …, 2016 - ACS Publications
Similar to its eukaryotic counterpart, the prokaryotic cytoskeleton is essential for the
structural and mechanical properties of bacterial cells. The essential protein FtsZ is a central …

A polymerization-associated structural switch in FtsZ that enables treadmilling of model filaments

JM Wagstaff, M Tsim, MA Oliva, A García-Sanchez… - MBio, 2017 - Am Soc Microbiol
Bacterial cell division in many organisms involves a constricting cytokinetic ring that is
orchestrated by the tubulin-like protein FtsZ. FtsZ forms dynamic filaments close to the …

Cell Cycle Machinery in Bacillus subtilis

J Errington, LJ Wu - … cytoskeletons: filamentous protein polymers active in …, 2017 - Springer
Bacillus subtilis is the best described member of the Gram positive bacteria. It is a typical rod
shaped bacterium and grows by elongation in its long axis, before dividing at mid cell to …