Secretory and transmembrane proteins enter the endoplasmic reticulum (ER) as unfolded
proteins and exit as either folded proteins in transit to their target organelles or as misfolded …

Matching the power of high throughput screening to the chemical diversity of natural products -
Natural Product Reports (RSC Publishing) DOI:10.1039/C3NP70052F Royal Society of …

The hypoxic areas of solid cancers represent a negative prognostic factor irrespective of
which treatment modality is chosen for the patient. Still, after almost 80 years of focus on the …

The unfolded protein response (UPR) is an integrated, adaptive biochemical process that is
inextricably linked with cell homeostasis and paramount to maintenance of normal …

The endoplasmic reticulum (ER) orchestrates the production of membrane-bound and
secreted proteins. However, its capacity to process the synthesis and folding of protein is …

Introduction: The accumulation of misfolded proteins in the endoplasmic reticulum (ER)
generates a stress condition that engages the unfolded protein response (UPR). The UPR is …

Citrinin (CIT) is a polyketide-derived mycotoxin, which is produced by many fungal strains
belonging to the gerena Monascus, Aspergillus, and Penicillium. It has been postulated that …

Background: Patulin, the most common mycotoxin in apples and apple-derived products,
triggers apoptosis and has thus been considered for the treatment of cancer. Similar to …

Increased cellular protein production places stress on the endoplasmic reticulum (ER),
because many of the nascent proteins pass through the ER for folding and trafficking …

The survival rate for patients with oral squamous cell carcinoma (OSCC) has not seen
marked improvement in recent decades despite enhanced efforts in prevention and the …