Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

P Dey - Pharmacological research, 2019 - Elsevier
The dynamic and delicate interactions amongst intestinal microbiota, metabolome and
metabolism dictates human health and disease. In recent years, our understanding of gut …

The intestinal 3M (microbiota, metabolism, metabolome) zeitgeist–from fundamentals to future challenges

P Dey, SR Chaudhuri, T Efferth, S Pal - Free Radical Biology and Medicine, 2021 - Elsevier
The role of the intestine in human health and disease has historically been neglected and
was mostly attributed to digestive and absorptive functions. In the past two decades …

A toxic shrub turned therapeutic: The dichotomy of Nerium oleander bioactivities

R Sharma, S Singh, N Tewari, P Dey - Toxicon, 2023 - Elsevier
Nerium oleander L. is a medicinal plant, used for the treatment of cancers and
hyperglycemia across the world, especially in Indian sub-continent, Turkey, Morocco, and …

The Botanical Drug PBI-05204, a Supercritical CO2 Extract of Nerium Oleander, Inhibits Growth of Human Glioblastoma, Reduces Akt/mTOR Activities, and …

A Colapietro, P Yang, A Rossetti, A Mancini… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma multiform (GBM) is the most common primary glial tumor resulting in very low
patient survival despite current extensive therapeutic efforts. Emerging evidence suggests …

Combined transcriptome and metabolome analysis of Nerium indicum L. elaborates the key pathways that are activated in response to witches' broom disease

S Wang, S Wang, M Li, Y Su, Z Sun, H Ma - BMC Plant Biology, 2022 - Springer
Abstract Background Nerium indicum Mill. is an ornamental plant that is found in parks,
riversides, lakesides, and scenic areas in China and other parts of the world. Our recent …

Antioxidant, anti-inflammatory, anti-apoptotic, and skin regenerative properties of an Aloe vera-based extract of Nerium oleander leaves (nae-8®)

KF Benson, RA Newman, GS Jensen - Clinical, Cosmetic and …, 2015 - Taylor & Francis
Objective The goal for this study was to evaluate the effects of an Aloe vera-based Nerium
oleander extract (NAE-8®), compared to an extract of A. vera gel alone (ALOE), and to an …

[HTML][HTML] The pharmaco-toxicological conundrum of oleander: potential role of gut microbiome

P Dey - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Nerium oleander L., commonly known as oleander, is a toxic shrub and also a medicinal
plant. All parts of oleander are rich in cardiac glycosides that inhibits Na+/K+-ATPase and …

Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression

C Zhou, F Yu, P Zeng, T Zhang, H Huang… - Biochemical …, 2019 - Elsevier
The cardiac glycoside oleandrin is a main active constituent of the botanical anti-cancer
drug candidate PBI-05204, an extract of Nerium oleander. Here, we aimed to determine the …

Antiviral effects of oleandrin

RA Newman, KJ Sastry, R Arav-Boger… - Journal of …, 2020 - Taylor & Francis
Over the past 15 years, investigators have reported on the utility and safety of cardiac
glycosides for numerous health benefits including those as treatments for malignant …

Bioprospecting of South African plants as a unique resource for bioactive endophytic microbes

MA Abdalla, LJ McGaw - Frontiers in pharmacology, 2018 - frontiersin.org
South Africa has a long history and strong belief in traditional herbal medicines. Using
ethnobotanical knowledge as a lead, a large number of South African medicinal plants have …