Bromodomains (BRDs) are evolutionarily conserved protein–protein interaction modules
that are found in a wide range of proteins with diverse catalytic and scaffolding functions and …

The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few
therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a …

Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …

Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer and one
of the most aggressive malignancies worldwide. Despite continuous efforts to identify …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Chronic hexavalent chromium [Cr (VI)] exposure causes lung cancer and other types of
cancer; however, the mechanism of Cr (VI) carcinogenesis remains to be clearly defined …

Triple-negative breast cancer (TNBC) is a metastatic disease and a formidable treatment
challenge as it does not respond to existing therapies. Epigenetic regulators play a crucial …

Malignant growth is defined by multiple aberrant cellular features, including metabolic
rewiring, inactivation of tumor suppressors and the activation of oncogenes. Even though …

Pharmacotherapeutic options are limited for hepatocellular carcinoma (HCC). Recently, we
identified the anti-tumor ligand MHC class I polypeptide-related sequence A (MICA) gene as …