Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …

The discovery and implementation of antibiotics in the early twentieth century transformed
human health and wellbeing. Chemical synthesis enabled the development of the first …

The synthesis of peptides by amide bond formation between suitably protected amino acids
is a fundamental part of the drug discovery process. However, the required coupling and …

New antibiotics are necessary to treat microbial pathogens that are becoming increasingly
resistant to available treatment. Despite the medical need, the number of newly approved …

This review covers some of the recent progress in the field of peptide antibiotics with a focus
on compounds with novel or established mode of action and with demonstrated efficacy in …

In this article strategies for the design and synthesis of natural product analogues are
summarized and illustrated with some selected examples. Proven strategies include …

Research in natural products, the genetically encoded small molecules produced by
organisms in an idiosyncratic fashion, deals with molecular structure, biosynthesis, and …

A review of efforts that have provided total syntheses of vancomycin and related
glycopeptide antibiotics, their agylcons, and key analogues is provided. It is a tribute to …

Re-engineering biosynthetic assembly lines, including nonribosomal peptide synthetases
(NRPS) and related megasynthase enzymes, is a powerful route to new antibiotics and other …

Ever since the world‐shaping discovery of penicillin, nature's molecular diversity has been
extensively screened for new medications and lead compounds in drug discovery. The …