Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

The rapid increase in both the lifespan and proportion of older adults is accompanied by the
unprecedented rise in age-associated chronic diseases, including sarcopenia and obesity …

Readily available nutrient-rich foods exploit our inherent drive to overconsume, creating an
environment of overnutrition. This transformative setting has led to persistent health issues …

Remyelination therapies, which are currently under development, have a great potential to
delay, prevent or even reverse disability in multiple sclerosis patients. Several models are …

The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin
effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also …

Neuroinflammation plays a crucial role in the onset and the progression of several
neuropathologies, from neurodegenerative disorders to migraine, from Rett syndrome to …

Multiple sclerosis (MS) is a disabling neurodegenerative disease that causes demyelination
and axonal degeneration of the central nervous system. Current treatments are partially …

Cerebral stroke is a common neurological disease and often causes severe neurological
deficits. With high morbidity, mortality, and disability rates, stroke threatens patients' life …

Chronic cerebral hypoperfusion leads to sustained demyelination and a unique response of
microglia. Triggering receptor expressed on myeloid cells 2 (Trem2), which is expressed …

Alzheimer's disease (AD) is the most common neurodegenerative disease. Increasing
studies suggest that mitochondrial dysfunction is closely related to the pathogenesis of AD …