Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide
range of anti-metabolic activities when tested against cultured cancer cells and to be an …

DNA methyltransferases catalyze the transfer of a methyl group from S‐adenosyl‐l‐
methionine to cytosine or adenine bases in DNA. These enzymes challenge the …

Folate, a water-soluble B vitamin, has recently garnered much attention because of its
purported role in the pathogenesis of cardiovascular disease, 1–4 neural tube defects, 5–7 …

Abstract Twenty AdoMet-dependent methyltransferases (MTases) have been characterized
structurally by X-ray crystallography and NMR. These include seven DNA MTases, five RNA …

▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

Mechanism-based inhibitors of enzymes, which mimic reactive intermediates in the reaction
pathway, have been deployed extensively in the analysis of metabolic pathways and as …

Although inherited p53 mutations are present in all somatic cells, malignant transformation is
limited to certain organs and target cells. The analysis of 475 tumors in 91 families with p53 …

We have shown previously that de novo methylation activities persist in mouse embryonic
stem (ES) cells homozygous for a null mutation of Dnmt1 that encodes the major DNA …

Methylcytosine in DNA is genetically unstable. Methylated CpG (mCpG) sequences
frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in …

Base flipping is the phenomenon whereby a base in normal B-DNA is swung completely out
of the helix into an extrahelical position. It was discovered in 1994 when the first co-crystal …