Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

H Abou-El-Hassan, RM Rezende, S Izzy… - Nature …, 2023 - nature.com
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality. The innate and
adaptive immune responses play an important role in the pathogenesis of TBI. Gamma-delta …

Gut microbiota as a key regulator of intestinal mucosal immunity

J Wang, M He, M Yang, X Ai - Life Sciences, 2024 - Elsevier
Gut microbiota is a complex microbial community with the ability of maintaining intestinal
health. Intestinal homeostasis largely depends on the mucosal immune system to defense …

Interplay between Microbiota and γδ T Cells: Insights into Immune Homeostasis and Neuro-Immune Interactions

AA Mohamed, BK Al-Ramadi… - International journal of …, 2024 - mdpi.com
The gastrointestinal (GI) tract of multicellular organisms, especially mammals, harbors a
symbiotic commensal microbiota with diverse microorganisms including bacteria, fungi …

Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease

JR Lopes, X Zhang, J Mayrink… - Proceedings of the …, 2023 - National Acad Sciences
Emerging evidence suggests that dysregulation of neuroinflammation, particularly that
orchestrated by microglia, plays a significant role in the pathogenesis of Alzheimer's disease …

Dietary nucleic acids promote oral tolerance through innate sensing pathways in mice

T Yang, T Li, Y Xing, M Cao, M Zhang, Q Leng… - Nature …, 2024 - nature.com
Oral tolerance is essential for intestinal homeostasis and systemic immune function.
However, our understanding of how oral tolerance is maintained is inadequate. Here we …

Role of innate T cells in necrotizing enterocolitis

J Liu, S Joseph, K Manohar, J Lee, JP Brokaw… - Frontiers in …, 2024 - frontiersin.org
Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting
preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of …

Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice

LM Cox, BK Tatematsu, L Guo, DS LeServe… - Brain, Behavior, and …, 2024 - Elsevier
Intestinal γδ T cells play an important role in shaping the gut microbiota, which is critical not
only for maintaining intestinal homeostasis but also for controlling brain function and …

The role of gut dysbiosis in the loss of intestinal immune cell functions and viral pathogenesis

F Fakharian, S Thirugnanam, DA Welsh, WK Kim… - Microorganisms, 2023 - mdpi.com
The gut microbiome plays a critical role in maintaining overall health and immune function.
However, dysbiosis, an imbalance in microbiome composition, can have profound effects on …

The Formidable Guardian: Type 3 Immunity in the Intestine of Pigs

Z Yang, D Zhang, Z Jiang, J Peng, H Wei - Virulence, 2024 - Taylor & Francis
Well-intestinal health is crucial for better growth performance in pigs. Type 3 immunity, which
is one of the three types of immune responses in mammals, plays a vital role in maintaining …

From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy

D Dora, E Szőcs, Á Soós, V Halasy, C Somodi… - Frontiers in …, 2024 - frontiersin.org
This comprehensive review undertakes a multidisciplinary exploration of the gut-lung axis,
from the foundational aspects of anatomy, embryology, and histology, through the functional …