Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate
vast protein diversity from a limited number of genes. The mechanisms and outcomes of …

Understanding how human genetics influence infectious disease susceptibility offers the
opportunity for new insights into pathogenesis, potential drug targets, risk stratification …

Here we use deep sequencing to identify sources of variation in mRNA splicing in the
dorsolateral prefrontal cortex (DLPFC) of 450 subjects from two aging cohorts. Hundreds of …

Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple …

Circular RNAs (circRNAs) are widely expressed noncoding RNAs. However, their
biogenesis and possible functions are poorly understood. Here, by studying circRNAs that …

Summary N 6-methyladenosine (m 6 A) modification occurs co-transcriptionally and impacts
pre-mRNA processing; however, the mechanism of co-transcriptional m 6 A-dependent …

Post-transcriptional gene regulation (PTGR) concerns processes involved in the maturation,
transport, stability and translation of coding and non-coding RNAs. RNA-binding proteins …

Zea mays is an important genetic model for elucidating transcriptional networks.
Uncertainties about the complete structure of mRNA transcripts limit the progress of research …