The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

The TRP (“transient receptor potential”) family of ion channels now comprises more than 30
cation channels, most of which are permeable for Ca2+, and some also for Mg2+. On the …

Hypothalamic neural circuits regulate instinctive behaviors such as food seeking, the
fight/flight response, socialization, and maternal care. Here, we identified microdeletions on …

Transient receptor potential (TRP) proteins form plasma-membrane cation channels that act
as sensors for diverse cellular stimuli. Here, we report a novel activation mechanism …

Introduction• I CRAC• Orais• STIM1• STIM2• STIM1, STIM2 and Ca2+ oscillations• TRPCs
and SOCE• Conclusions The process of store‐operated Ca2+ entry (SOCE), whereby Ca2+ …

The Rho family of small guanosine triphosphatases (Rho GTPases: RhoA, Cdc42, and
Rac1) regulates many aspects of cell behavior, including actin dynamics and cell migration …

Mammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are
a large family of multimeric cation channels that act, or putatively act, as sensors of one or …

2-Aminoethoxydiphenyl borate (2-APB) has been widely used to examine the roles of
inositol 1, 4, 5-trisphosphate receptors (IP 3 Rs) and store-operated Ca 2+ entry and is an …

Transient receptor potential canonical (TRPC) channels are Ca 2+-permeable nonselective
cation channels implicated in diverse physiological functions, including smooth muscle …