Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of
osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain …

Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Importance Synovitis is common and is associated with progression of structural
characteristics of knee osteoarthritis. Intra-articular corticosteroids could reduce cartilage …

Knee osteoarthritis (OA) is a leading cause of pain and disability. Although conventional
treatments show modest benefits, pilot and phase I/II trials with bone marrow (BM) and …

Articular cartilage defect repair is a problem that has long plagued clinicians. Although
mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they …

Background Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most
tenosynovial giant-cell tumors. This observation has led to the discovery and clinical …

Objective To systematically review the literature on the relationship between markers of
inflammation and pain in patients with knee osteoarthritis (OA). Methods We searched …

Background Mesenchymal stromal cells are a promising option to treat knee osteoarthritis.
Their safety and usefulness must be confirmed and the optimal dose established. We tested …

Background Osteoarthritis (OA) is a common and debilitating chronic degenerative disease
of the joints. Currently, cell-based therapy is being explored to address the repair of …

OBJECTIVE: In an effort to evolve semi-quantitative scoring methods based upon limitations
identified in existing tools, integrating expert readers' experience with all available scoring …