Hyperpolarized [1-13C]pyruvate-to-[1-13C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane

Y Rao, S Gammon, NM Zacharias… - Proceedings of the …, 2020 - National Acad Sciences
Hyperpolarized [1-13C] pyruvate magnetic resonance spectroscopic imaging (MRSI) is a
noninvasive metabolic-imaging modality that probes carbon flux in tissues and infers the …

Hyperpolarized product selective saturating‐excitations for determination of changes in metabolic reaction rates in real‐time

T Harris, S Uppala, N Lev‐Cohain… - NMR in …, 2020 - Wiley Online Library
Investigation of hyperpolarized substrate metabolism has been showing utility in real‐time
determination of in‐cell and in vivo enzymatic activities. Intracellular reaction rates may vary …

Breast Cancer Tissue Explants: An Approach to Develop Personalized Therapy in Public Health Services

P Carranza-Rosales, D Valencia-Mercado… - Journal of Personalized …, 2023 - mdpi.com
Breast cancer is one of the main causes of death worldwide. Lately, there is great interest in
developing methods that assess individual sensitivity and/or resistance of tumors to …

Curbing action potential generation or ATP-synthase leads to a decrease in in-cell pyruvate dehydrogenase activity in rat cerebrum slices

B Grieb, S Uppala, G Sapir, D Shaul, JM Gomori… - Scientific Reports, 2021 - nature.com
Direct and real-time monitoring of cerebral metabolism exploiting the drastic increase in
sensitivity of hyperpolarized 13C-labeled metabolites holds the potential to report on neural …

Correlation between lactate dehydrogenase/pyruvate dehydrogenase activities ratio and tissue pH in the perfused mouse heart: A potential noninvasive indicator of …

D Shaul, A Azar, G Sapir, S Uppala… - NMR in …, 2021 - Wiley Online Library
Cardiovascular diseases account for more than 30% of all deaths worldwide and many
could be ameliorated with early diagnosis. Current cardiac imaging modalities can assess …

Real-Time Non-Invasive and Direct Determination of Lactate Dehydrogenase Activity in Cerebral Organoids—A New Method to Characterize the Metabolism of Brain …

G Sapir, DJ Steinberg, RI Aqeilan, R Katz-Brull - Pharmaceuticals, 2021 - mdpi.com
Organoids are a powerful tool in the quest to understand human diseases. As the
developing brain is extremely inaccessible in mammals, cerebral organoids (COs) provide a …

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C] Pyruvate and 13C/31P NMR Spectroscopy

D Shaul, G Sapir, N Lev-Cohain, J Sosna… - JoVE (Journal of …, 2023 - jove.com
Metabolism is the basis of important processes in cellular life. Characterizing how metabolic
networks function in living tissues provides crucial information for understanding the …

Differentiation of Heterogeneous Mouse Liver from HCC by Hyperpolarized 13C Magnetic Resonance

N Lev-Cohain, G Sapir, S Uppala, A Nardi-Schreiber… - Sci, 2021 - mdpi.com
The clinical characterization of small hepatocellular carcinoma (HCC) lesions in the liver
and differentiation from heterogeneous inflammatory or fibrotic background is important for …

[PDF][PDF] Phytochemical Characteristic Analysis and Biological Activity for Capparis spinosa L. Fruit extract

SA Neamah, IQ Falih, S Albukhaty - Rafidain Journal of Science, 2024 - iasj.net
Alternative medicine and herbal treatment are among the methods inherited by the people of
the Middle East. In the current study, we evaluated the chemical composition of the fruit of …

Accumulation of 3‐aminopropylphosphonate in the ex vivo brain observed by phosphorus‐31 nuclear magnetic resonance

D Shaul, B Grieb, N Lev‐Cohain, J Sosna… - NMR in …, 2022 - Wiley Online Library
3‐aminopropylphosphonate (3‐APP) is known for its use as an exogenous indicator of
extracellular volume and pH in phosphorus‐31 nuclear magnetic resonance (31P NMR) …