The roles of integrin α5β1 in human cancer

J Hou, D Yan, Y Liu, P Huang, H Cui - OncoTargets and therapy, 2020 - Taylor & Francis
Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …

Reelin through the years: From brain development to inflammation

A Alexander, J Herz, L Calvier - Cell reports, 2023 - cell.com
Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …

Lymphoangiocrine signals promote cardiac growth and repair

X Liu, E De la Cruz, X Gu, L Balint, M Oxendine-Burns… - Nature, 2020 - nature.com
Recent studies have suggested that lymphatics help to restore heart function after cardiac
injury,,,,–. Here we report that lymphatics promote cardiac growth, repair and …

Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis

F Qu, SC Brough, W Michno, CJ Madubata… - Nature Cell …, 2023 - nature.com
Brain metastases represent an important clinical problem for patients with small-cell lung
cancer (SCLC). However, the mechanisms underlying SCLC growth in the brain remain …

Integrins promote axonal regeneration after injury of the nervous system

B Nieuwenhuis, B Haenzi, MR Andrews… - Biological …, 2018 - Wiley Online Library
Integrins are cell surface receptors that form the link between extracellular matrix molecules
of the cell environment and internal cell signalling and the cytoskeleton. They are involved in …

Graphene oxide induced perturbation to plasma membrane and cytoskeletal meshwork sensitize cancer cells to chemotherapeutic agents

J Zhu, M Xu, M Gao, Z Zhang, Y Xu, T Xia, S Liu - ACS nano, 2017 - ACS Publications
The outstanding physicochemical properties endow graphene materials (eg, graphene
oxide, GO) with beneficial potentials in diverse biomedical fields such as bioimaging, drug …

Canonical and non-canonical reelin signaling

HH Bock, P May - Frontiers in cellular neuroscience, 2016 - frontiersin.org
Reelin is a large secreted glycoprotein that is essential for correct neuronal positioning
during neurodevelopment and is important for synaptic plasticity in the mature brain …

B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3

L Lin, L Cao, Y Liu, K Wang, X Zhang, X Qin, D Zhao… - Leukemia, 2019 - nature.com
Abstract B7-H3 (CD276) is broadly overexpressed by multiple human cancers. It plays a vital
role in tumor progression and has been accepted as one of the inhibitory B7 family …

The cancer cell adhesion resistome: mechanisms, targeting and translational approaches

E Dickreuter, N Cordes - Biological chemistry, 2017 - degruyter.com
Cell adhesion-mediated resistance limits the success of cancer therapies and is a great
obstacle to overcome in the clinic. Since the 1990s, where it became clear that adhesion of …

The lymphatic vasculature in cardiac development and ischemic heart disease

X Liu, G Oliver - Circulation research, 2023 - Am Heart Assoc
In recent years, the lymphatic system has received increasing attention due to the fast-
growing number of findings about its diverse novel functional roles in health and disease. It …