The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …

Although many studies have been exploring the mechanisms driving NETs formation, much
less attention has been paid to the degradation and elimination of these structures. The …

Summary Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for the
immune response to cancer and pathogen infection. Here, we discover that cGAS-DNA …

Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

In various autoimmune diseases, dysfunctional TREX1 (T hree prime R epair Ex onuclease
1) leads to accumulation of endogenous single-stranded DNA (ssDNA), double-stranded …

TREX1 encodes a major cellular DNA exonuclease. Mutations of this gene in human cause
cellular accumulation of DNA that triggers autoimmune diseases including Aicardi …

Highlights•The cGAS-STING pathway signals cytosolic DNA resulting from endogenous
DNA damage.•This pathway has both pro-tumoral and anti-tumoral roles depending on the …

We have uncovered a role for the promyelocytic leukemia (PML) gene and novel PML-like
DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE …

Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to
the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned …

The presence of DNA in the cytoplasm of tumor cells induces the dendritic cell to produce
type-I IFNs. Classically, the presence of foreign DNA in host cells' cytoplasm during viral …