Matrix‐assisted laser desorption/ionisation mass spectrometry (MALDI‐TOF MS) is
increasingly used by clinical microbiology laboratories to cope with the need for rapid, cost …

Background Current methods to identify, classify, and predict tumor behavior mostly rely on
histology, immunohistochemistry, and molecular determinants. However, better predictive …

Increasingly, scientific studies yield functional data, in which the ideal units of observation
are curves and the observed data consist of sets of curves that are sampled on a fine grid …

Background In mass spectrometry (MS) based proteomic data analysis, peak detection is an
essential step for subsequent analysis. Recently, there has been significant progress in the …

Normalization is critically important for the proper interpretation of matrix-assisted laser
desorption/ionization (MALDI) imaging datasets. The effects of the commonly used …

Cells often adopt different phenotypes, dictated by tissue-specific or local signals such as
cell-cell and cell-matrix contacts or molecular micro-environment. This holds in extremis for …

Motivation: Comparing two or more complex protein mixtures using liquid chromatography
mass spectrometry (LC-MS) requires multiple analysis steps to locate and quantitate natural …

Profiling and imaging biological specimens using MALDI mass spectrometry has significant
potential to contribute to our understanding and diagnosis of disease. The technique is …

The amount of data produced by spectral imaging techniques, such as mass spectrometry
imaging, is rapidly increasing as technology and instrumentation advances. This, combined …

We describe a novel tissue profiling strategy that improves the cellular specificity and
analysis throughput of protein profiles obtained by direct MALDI analysis. The new approach …