Immunotherapy has emerged as a revolutionary approach in cancer therapy, and recent
advancements hold significant promise for breast cancer (BCa) management. Employing the …

The etiology of intervertebral disc degeneration (IDD) and osteoarthritis (OA) is complex and
multifactorial. Both predisposing genes and environmental factors are involved in the …

Chitinase-like proteins have multiple biological functions that promote tumor growth,
angiogenesis and metastasis. Expression of CHI3L2, which is similar in structure to CHI3L1 …

Histone lysine-specific demethylase 1 (LSD1) is hyperactive in breast cancer, which is
associated with the metastasis of the tumor. Current irreversible LSD1 inhibitors are all …

Recent therapeutic advances have significantly uplifted the quality of life in breast cancer
patients, yet several impediments block the road to disease-free survival. This involves …

Epithelial-to-mesenchymal transition (EMT) is a complex cellular process that allows cells to
change their phenotype from epithelial to mesenchymal-like. Type 3 EMT occurs during …

RNA-binding proteins (RBPs) refer to a class of proteins that participate in alternative
splicing, RNA stability, polyadenylation, localization and translation of RNAs, thus regulating …

Abstract Background The protein CHI3L1 contributes to cancer development by several
mechanisms, including stimulation of angiogenesis and invasion as well as …

Objectives Epithelial ovarian cancer (EOC) is considered to be a prevalent female
malignancy with both high incidence and mortality. It is reported that RNA-binding protein 3 …

Metformin (Met), a widely used type II diabetes medication, has shown anti-cancer
properties in various cancers. RBMS3 is a tumor suppressor implicated in several cancers …