The emergence of multidrug-resistant Gram-negative bacteria that cause nosocomial
infections is a growing problem worldwide. Colistin was first introduced in 1952 and was …

In this review, we provide an updated summary on colistin pharmacokinetics and
pharmacodynamics. Colistin is an old molecule that is frequently used as last-line treatment …

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the
treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria …

'Old'colistin and polymyxin B are increasingly used as last-line therapy against multidrug-
resistant Gram-negative bacteria Pseudomonas aeruginosa, Acinetobacter baumannii, and …

LC–MS/MS is an increasingly important tool in therapeutic drug monitoring as it offers
increased sensitivity and specificity compared to other methods, and may be the only viable …

Colistin pharmacokinetics (PK) was investigated in young healthy volunteers after a 1‐h
infusion of 80 mg (1 million international units (MIU)) of the prodrug colistin …

Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasingly common cause of
health care-associated urinary tract infections. Antimicrobials with in vitro activity against …

Antibiotic resistant bacteria and antibiotic residues can enter the environment when using
animal manure as fertilizer. Twenty-five mixed beef cattle farmyard manure samples and 9 …

The example of colistin demonstrated that state-of-the-art analytical, microbiological and
pharmacokinetic/pharmacodynamic methods can facilitate optimized use of 'old'antibiotics in …

Colistin is a re-emerging old antibiotic that is used to treat multidrug-resistant infections in
critically ill patients. It corresponds to a mixture of at least 30 different compounds …