In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

The mechanistic/mammalian target of rapamycin (mTOR) is a downstream mediator in the
phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways, which plays a pivotal role in …

N 6-Methyladenosine (m 6 A) is the most prevalent post-transcriptional modification of
eukaryotic mRNA and long noncoding RNA. m 6 A mediates its effects primarily by recruiting …

Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that
is pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse …

Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome that presents with
diverse and complex clinical features and involves multiple human systems. TSC-related …

Ovarian cancer is the most lethal gynecologic malignancy in the United States, with an
estimated 22,530 new cases and 13,980 deaths in 2019. Recent studies have indicated that …

Hyperactivation of mTOR kinase by mutations in the PI3K/mTOR pathway or by crosstalk
with other mutant cancer drivers, such as RAS, is a feature of many tumors. Multiple …

Glucose is a major requirement for biological life. Its concentration is constantly sensed at
the cellular level, allowing for adequate responses to any changes of glucose availability …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

Cells maintain and dynamically change their proteomes according to the environment and
their needs. Mechanistic target of rapamycin (mTOR) is a key regulator of proteostasis …