The MONARK study was a pilot randomized trial comparing the safety and efficacy of
lopinavir-ritonavir (LPV/r) monotherapy to those of LPV/r-zidovudine-lamivudine triple …

In Brazil, where three distinct HIV-1 subtypes (B, F, and C) cocirculate, a significant portion of
the HIV-infected population has been exposed to antiretroviral drugs. This study analyzes …

Background Analysis of potentially different impact of Lopinavir/Ritonavir (LPV/r) on non-B
subtypes is confounded by dissimilarities in the conditions existing in different countries. We …

Santos is a Brazilian port city with high HIV incidence, high primary antiretroviral resistance
levels, high HIV-1 BF recombinants prevalence, and high rates of antiretroviral virologic …

Protease inhibitors are the core component of second-line therapy in resource-limited
settings and are used in specific situations in first-line therapy. Use of second-line regimens …

In the present study, we investigated the influence of HIV-1 subtype in the response to the
dendritic cell (DC) therapeutic vaccine for HIV. HIV-1 viral load and TCD8+/TCD4+ cell …

Here we review the prevalence of HIV-1 primary drug resistance in Latin America and
Caribbean using meta-analysis as well as time-series modeling. We also discuss whether …

The MONARK study was a pilot randomized trial comparing the safety and efficacy of
lopinavir-ritonavir (LPV/r) monotherapy to those of LPV/r-zidovudine-lamivudine triple …

HIV-1 has the ability to rapidly diversify and adapt to changes in its environment, such as
evading the host immune response, altering cell tropism, and developing resistance to …

The work presented in this thesis represents the culmination of three distinct, but intertwined
phases of my involvement with the national HIV treatment program in Cambodia. I first went …