Tight coupling between biochemical and mechanical properties of the actin cytoskeleton
drives a large range of cellular processes including polarity establishment, morphogenesis …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

ADF/cofilins are key regulators of actin dynamics during cellular motility, yet their precise
role and mechanism of action are shrouded in ambiguity. Direct observation of actin …

Intracellular and extracellular mechanical forces affect the structure and dynamics of the
actin cytoskeleton. However, the underlying molecular and biophysical mechanisms …

Summary Actin-depolymerizing factor (ADF)/cofilins contribute to cytoskeletal dynamics by
promoting rapid actin filament disassembly. In the classical view, ADF/cofilin sever filaments …

Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling
inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper …

Actin-based motility demands the spatial and temporal coordination of numerous regulatory
actin-binding proteins (ABPs)[1], many of which bind with affinities that depend on the …

Force transmission through the actin cytoskeleton plays a central role in cell movements,
shape change, and internal organization. Dynamic reorganization of actin filaments by an …

We determined the flexural (bending) rigidities of actin and cofilactin filaments from a cosine
correlation function analysis of their thermally driven, two-dimensional fluctuations in shape …

Background Actin-based cellular motility requires spatially and temporally coordinated
remodeling of a network of branched actin filaments. This study investigates how cofilin and …