The transcription factor CREB? for'cyclic AMP response element-binding protein'? functions
in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in …

Cyclin A is particularly interesting among the cyclin family because it can activate two
different cyclin-dependent kinases (CDKs) and functions in both S phase and mitosis. An …

Background Aberrant expression of circular RNAs (circRNAs) contributes to the initiation
and progression of human malignancies, but the underlying mechanisms remain largely …

The E2F transcription factor plays a pivotal role in the timely activation of gene expression
during mammalian cell cycle progression, whereas pRB and related proteins control cell …

Rapamycin has potent immunosuppressive properties reflecting its ability to disrupt cytokine
signaling that promotes lymphocyte growth and differentiation. In IL-2-stimulated T cells …

SPERMIOGENESIS is a complex process by which postmeiotic male germ cells differentiate
into mature spermatozoa. This process involves remarkable structural and biochemical …

Despite advances in molecularly characterizing glioblastoma (GBM), metabolic alterations
driving its aggressive phenotype are only beginning to be recognized. Integrative cross …

Obesity is the result of numerous, interacting behavioral, physiological, and biochemical
factors. One increasingly important factor is the generation of additional fat cells, or …

Bovine leukemia virus (BLV) infection is widespread in the US dairy industry and the
majority of producers do not actively try to manage or reduce BLV incidence within their …

The extraordinary ability of the liver to regenerate after injury or resection has long
fascinated physicians, scientists, and lay persons. The earliest allusion to the liver's …