Definition, causes, pathogenesis, and consequences of chronic obstructive pulmonary disease exacerbations

AI Ritchie, JA Wedzicha - Clinics in chest medicine, 2020 - chestmed.theclinics.com
Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are episodes of
symptom worsening 1 that have significant adverse consequences for patients. 2 The …

Inflammation and skeletal muscle wasting during cachexia

JM Webster, LJAP Kempen, RS Hardy… - Frontiers in …, 2020 - frontiersin.org
Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Epithelial barrier dysfunction in chronic respiratory diseases

FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Comorbidities of COPD

A Cavaillès, G Brinchault-Rabin… - European …, 2013 - Eur Respiratory Soc
By 2020, chronic obstructive pulmonary disease (COPD) will be the third cause of mortality.
Extrapulmonary comorbidities influence the prognosis of patients with COPD. Tobacco …

Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort

H Müllerova, DJ Maselli, N Locantore, J Vestbo… - Chest, 2015 - Elsevier
OBJECTIVE: Exacerbations of COPD requiring hospital admission have important clinical
and societal implications. We sought to investigate the incidence, recurrence, risk factors …

Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis

WQ Gan, SFP Man, A Senthilselvan, DD Sin - Thorax, 2004 - thorax.bmj.com
Background: Individuals with chronic obstructive pulmonary disease (COPD) are at
increased risk of cardiovascular diseases, osteoporosis, and muscle wasting. Systemic …

COPD exacerbations: defining their cause and prevention

JA Wedzicha, TAR Seemungal - The lancet, 2007 - thelancet.com
Exacerbations of chronic obstructive pulmonary disease (COPD) are episodes of worsening
of symptoms, leading to substantial morbidity and mortality. COPD exacerbations are …

Acute pulmonary embolism

VF Tapson - Management of Acute Decompensated Heart …, 2005 - api.taylorfrancis.com
The implications of a particular embolic event depend upon the extent of obstruction of the
crosssectional area of the pulmonary arterial bed as well as upon the presence or absence …

Association of cardiovascular disease with respiratory disease

P Carter, J Lagan, C Fortune, DL Bhatt, J Vestbo… - Journal of the American …, 2019 - jacc.org
Background: The relationship between respiratory diseases and individual cardiovascular
diseases, and the impact of cardiovascular diseases on mortality in patients with respiratory …

Increased risk of myocardial infarction and stroke following exacerbation of COPD

GC Donaldson, JR Hurst, CJ Smith, RB Hubbard… - Chest, 2010 - Elsevier
Objective Patients with COPD are at risk for cardiovascular events. This is attributed to
increased systemic inflammation. The course of COPD is punctuated by exacerbations …