Repair and genetic consequences of endogenous DNA base damage in mammalian cells
DE Barnes, T Lindahl - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …
major challenge of faithfully maintaining their genetic material under a constant attack from …
The base excision repair process: comparison between higher and lower eukaryotes
The base excision repair (BER) pathway is essential for maintaining the stability of DNA in
all organisms and defects in this process are associated with life-threatening diseases. It is …
all organisms and defects in this process are associated with life-threatening diseases. It is …
Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation
C Rada, JM Di Noia, MS Neuberger - Molecular cell, 2004 - cell.com
AID-mediated deamination of dC residues within the immunoglobulin locus generates dU:
dG lesions whose resolution leads to class-switch recombination and somatic …
dG lesions whose resolution leads to class-switch recombination and somatic …
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil-and UNG-backup uracil-excision activities and increases cancer predisposition of …
K Kemmerich, FA Dingler, C Rada… - Nucleic acids …, 2012 - academic.oup.com
Abstract Deamination of cytosine (C), 5-methylcytosine (mC) and 5-hydroxymethylcytosine
(hmC) occurs spontaneously in mammalian DNA with several hundred deaminations …
(hmC) occurs spontaneously in mammalian DNA with several hundred deaminations …
Uracil–DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms
HS Pettersen, O Sundheim, KM Gilljam… - Nucleic acids …, 2007 - academic.oup.com
Abstract DNA glycosylases UNG and SMUG1 excise uracil from DNA and belong to the
same protein superfamily. Vertebrates contain both SMUG1 and UNG, but their distinct roles …
same protein superfamily. Vertebrates contain both SMUG1 and UNG, but their distinct roles …
Genome-wide alterations of uracil distribution patterns in human DNA upon chemotherapeutic treatments
Numerous anti-cancer drugs perturb thymidylate biosynthesis and lead to genomic uracil
incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if …
incorporation contributing to their antiproliferative effect. Still, it is not yet characterized if …
The transcription factor, NFI/CTF plays a positive regulatory role in expression of the hSMUG1 gene
I Elateri, S Muller-Weeks, S Caradonna - DNA repair, 2003 - Elsevier
SMUG1 is a recently discovered uracil-DNA glycosylase with the ability to remove uracil
from single-stranded as well as double-stranded DNA. SMUG1 also has the capacity to …
from single-stranded as well as double-stranded DNA. SMUG1 also has the capacity to …
Mitochondrial inhibition of uracil-DNA glycosylase is not mutagenic
Abstract Background Uracil DNA glycosylase (UDG) plays a major role in repair of uracil
formed due to deamination of cytosine. UDG in human cells is present in both the nucleus …
formed due to deamination of cytosine. UDG in human cells is present in both the nucleus …
[图书][B] Biochemical characterization and mutational analysis of human uracil-DNA glycosylase
CY Chen - 2005 - search.proquest.com
PCR-based codon-specific random mutagenesis and site-specific mutagenesis were
performed to construct a library of 18 amino acid changes at Arg276 in the conserved …
performed to construct a library of 18 amino acid changes at Arg276 in the conserved …