Plant phenolics: Bioavailability as a key determinant of their potential health-promoting applications

P Cosme, AB Rodríguez, J Espino, M Garrido - Antioxidants, 2020 - mdpi.com
Phenolic compounds are secondary metabolites widely spread throughout the plant
kingdom that can be categorized as flavonoids and non-flavonoids. Interest in phenolic …

Nanoformulations to enhance the bioavailability and physiological functions of polyphenols

B Yang, Y Dong, F Wang, Y Zhang - Molecules, 2020 - mdpi.com
Polyphenols are micronutrients that are widely present in human daily diets. Numerous
studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and …

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential

DR Telange, AT Patil, AM Pethe, H Fegade… - European Journal of …, 2017 - Elsevier
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous
solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin. The APLC …

Recent advances and future prospects of phyto-phospholipid complexation technique for improving pharmacokinetic profile of plant actives

J Khan, A Alexander, S Saraf, S Saraf - Journal of controlled release, 2013 - Elsevier
The phyto-phospholipid complexation technique has emerged as one of the leading
methods of improving bioavailability of phytopharmaceuticals having poor competency of …

Herbal nanomedicines: Recent advancements, challenges, opportunities and regulatory overview

PK Teja, J Mithiya, AS Kate, K Bairwa, SK Chauthe - Phytomedicine, 2022 - Elsevier
Abstract Background Herbal Nano Medicines (HNMs) are nano-sized medicine containing
herbal drugs as extracts, enriched fractions or biomarker constituents. HNMs have certain …

Recent expansion of pharmaceutical nanotechnologies and targeting strategies in the field of phytopharmaceuticals for the delivery of herbal extracts and bioactives

A Alexander, RJ Patel, S Saraf, S Saraf - Journal of controlled release, 2016 - Elsevier
Application of pharmaceutical nanotechnology (nanomedicines) for plant actives and
extracts, is gaining a tremendous growth and interest among the scientists. This emerging …

The Why, Where, Who, How, and What of the vesicular delivery systems

B Kapoor, R Gupta, M Gulati, SK Singh… - Advances in colloid and …, 2019 - Elsevier
Though vesicular delivery systems have been widely explored and reviewed, no
comprehensive review exists that covers their development from the inception of the concept …

Nano-phytosome: a developing platform for herbal anti-cancer agents in cancer therapy

A Babazadeh, M Zeinali, H Hamishehkar - Current drug targets, 2018 - ingentaconnect.com
Background: Cancer is one of the main causes of death in the world. It has not yet been
cured in an efficient manner and has remained a major challenge for current chemotherapy …

Drug-phospholipid complex—a go through strategy for enhanced oral bioavailability

K Kuche, N Bhargavi, CP Dora, S Jain - AAPS PharmSciTech, 2019 - Springer
Among many, the oral route of delivery is considered to be the most favorable route with the
highest patient compliance. The main issue with oral delivery is the environmental …

Critical review of lipid-based nanoparticles as carriers of neuroprotective drugs and extracts

F Fernandes, M Dias-Teixeira, C Delerue-Matos… - Nanomaterials, 2021 - mdpi.com
The biggest obstacle to the treatment of diseases that affect the central nervous system
(CNS) is the passage of drugs across the blood-brain barrier (BBB), a physical barrier that …