Solid tumors are complex organ-like structures that consist not only of tumor cells but also of
vasculature, extracellular matrix (ECM), stromal, and immune cells. Often, this tumor …

Colorectal cancer (CRC) has the second highest mortality rate among all cancers
worldwide. Surgery, chemotherapy, radiotherapy, molecular targeting and other treatment …

Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate
intracellular signalling pathways that promote cancer cell survival and tumour growth …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Background Pancreatic cancer is one of the most lethal type of cancers, with an overall five-
year survival rate of less than 5%. It is usually diagnosed at an advanced stage with limited …

Purpose: A subpopulation of pancreatic ductal adenocarcinoma (PDAC) cells is thought to
be inherently resistant to chemotherapy or to give rise to tumor cells that become resistant …

In pancreatic ductal adenocarcinoma (PDAC), the abundant stromal cells which comprise
the tumor microenvironment constitute more than 90% of the primary tumor bulk. Moreover …

Chemoresistance is a formidable issue in clinical anticancer therapy and is pertinent to the
lowered efficacies of chemotherapeutics and the activated tumor self-repairing proceedings …

Overcoming resistance to chemotherapy is a major and unmet medical challenge in the
treatment of pancreatic cancer. Poor drug delivery due to stromal barriers in the tumor …

Cancer stem cells (CSCs) play a vital role in tumor initiation, progression, metastasis,
chemoresistance, and recurrence. The mechanisms that maintain the stemness of these …