Background Tumor microenvironment is a complex system composed of a largely altered
extracellular matrix with different cell types that determine angiogenic responses and tumor …

Highlights•Systems biology approaches support drug development efforts.•Models of
angiogenesis aid in testing anti-angiogenic therapeutic strategies.•Models provide novel …

Clusterin (CLU) is a stress-responding protein associated with cytoprotection in a broad
range of pathological processes. However, clusterin's function in diabetes-induced …

During the last two decades, the pharmaceutical industry has progressed from detecting
small molecules to designing biologic-based therapeutics. Amino acid-based drugs are a …

Peptides are emerging as a promising candidate for therapeutic as well as diagnostic
applications within the domain of clinical and scientific research. They are recognized for …

Peptides provide promising templates for developing drugs to occupy a middle space
between small molecules and antibodies and for targeting 'undruggable'intracellular protein …

Metastasis is the main cause of mortality in cancer patients. Though there are many anti-
cancer drugs targeting primary tumor growth, anti-metastatic agents are rarely developed …

The extracellular matrix is a complex network of fibrous and nonfibrous molecules that not
only provide structure to the lung but also interact with and regulate the behaviour of the …

Rg1 is a predominant protopanaxatriol-type of ginsenoside found in Panax ginseng, and it
has been shown to have anti-cancer effects in multiple types of cancer cells. However, Rg1 …

Recent studies have shown that MMP-14 is highly expressed in a panel of human solid
tumors and poses as a potential molecular target for anticancer drugs. Currently, major …