Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

Extracellular concentrations of the predominant excitatory neurotransmitter, glutamate, and
related excitatory amino acids are maintained at relatively low levels to ensure an …

l‐Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five
types of high‐affinity Glu transporters (EAAT1–5) have been identified. The transporters …

Ischemic tolerance describes the adaptive biological response of cells and organs that is
initiated by preconditioning (ie, exposure to stressor of mild severity) and the associated …

Astrocytic glutamate transporters are considered an important target for neuroprotective
therapies as the function of these transporters is abnormal in stroke and other neurological …

Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

The G protein-coupled estrogen receptor GPR30 contributes to the neuroprotective effects of
17β-estradiol (E2); however, the mechanisms associated with this protection have yet to be …

Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability
associated with sustained oxidative stress, neuroinflammation, and cell death, affecting …

The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate
uptake in the brain and its dysregulation has been associated with multiple psychiatric and …

In this review, we briefly describe glutamate (Glu) metabolism and its specific transports and
receptors in the central nervous system (CNS). Thereafter, we focus on excitatory amino acid …