Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Cellular senescence, characterized by stable cell cycle arrest, plays an important role in
aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Cardiovascular diseases (CVDs) constitute the prime cause of global mortality, with an
immense impact on patient quality of life and disability. Clinical evidence has revealed a …

The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

The role of the microbiome in human aging is important: the microbiome directly impacts
aging through the gastrointestinal system. However, the microbial impact on skin has yet to …

Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …