Microglia are the predominant immune response cells and professional phagocytes of the
central nervous system (CNS) that have been shown to be important for brain development …

Chronic psychosocial stress is increasingly recognized as a risk factor for late-onset
Alzheimer's disease (LOAD) and associated cognitive deficits. Chronic stress also primes …

The results of several meta-analyses suggest that eicosapentaenoic acid (EPA)
supplementation is therapeutic in managing the symptoms of major depression. It was …

Dietary n-3 polyunsaturated fatty acids (PUFAs) are critical components of inflammatory
response and memory impairment. However, the mechanisms underlying the sensitizing …

Depression triggered by early-life stress has begun to attract wide attention due to its severe
symptoms and poor treatment outcomes. However, the pathophysiological mechanism for …

Our previous studies have reported that pre-stimulation of microglia before stress stimulation
is a possible strategy to prevent depression-like phenotypes; however, the molecular …

We and others have reported that systematic stimulation of the central innate immune
system by a low dose of lipopolysaccharide (LPS) can improve depression-like behavior in …

Sleep serves crucial learning and memory functions in both nervous and immune systems.
Microglia are brain immune cells that actively maintain health through their crucial …

Neuroimmune signaling is increasingly identified as a critical component of neuronal
processes underlying memory, emotion and cognition. The interactions of microglia and …

Neuroinflammatory processes are known to contribute to the cascade of events culminating
in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's …