Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …

Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

Although analysis of maternal plasma cell-free content has been employed for screening of
genetic abnormalities within a pregnancy, limited attention has been paid to its use for the …

The placenta is the interface between maternal and fetal circulations, integrating maternal
and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as …

Intrauterine growth restriction (IUGR) and preeclampsia (PE) are placental pathologies
known to complicate pregnancy and cause neonatal disorders. To date, there is a limited …

Assisted reproductive technologies (ART) are increasingly used, however little is known
about the long-term health of ART-conceived offspring. Weak selection of comparison …

Many studies have confirmed that extrachromosomal circular DNAs (eccDNAs/ecDNAs)
exist in tumor and normal cells independently of the chromosome and are essential for …

Background Birthweight marks an important milestone of health across the lifespan,
including cardiometabolic disease risk in later life. The placenta, a transient organ at the …

Protein tyrosine phosphatase, receptor type N2 (PTPRN2) encodes a major islet
autoantigen in type-1 diabetes. Previous genetic studies have shown its significant …