Crucial as molecular sensors for many vital physiological processes, seven-transmembrane
domain G protein-coupled receptors (GPCRs) comprise the largest family of proteins …

Membrane proteins present a challenge for structural biology. In this article, we review some
of the recent developments that advance the application of NMR to membrane proteins, with …

The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of
family AG protein-coupled receptors. The TSHR is of great importance for the growth and …

The years 2000 and 2007 witnessed milestones in current understanding of G protein-
coupled receptor (GPCR) structural biology. In 2000 the first GPCR, bovine rhodopsin, was …

Recently, much progress has been made in elucidating the chemistry and metabolism of
retinoids and carotenoids, as well as the structures of processing proteins related to vision …

Retinitis pigmentosa (RP) refers to a heterogeneous group of inherited diseases that result
in progressive retinal degeneration, characterized by visual field constriction and night …

Seven transmembrane G protein-coupled receptors (GPCRs) have gained much interest in
recent years as it is the largest class among cell surface receptors. G proteins lie in the heart …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Lipid bilayers are natural barriers of biological cells and cellular compartments. Membrane
proteins integrated in biological membranes enable vital cell functions such as signal …

A major current focus of structural work on G-protein-coupled receptors (GPCRs) pertains to
the investigation of their active states. However, for virtually all GPCRs, active agonist-bound …