We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Depression is a major contributor to the global burden of disease and disability, yet it is
poorly understood. Here we review data supporting a novel theoretical model for the biology …

BACKGROUND: Adult-onset stressors exert opposing effects on hippocampal neurogenesis
and cognition, with enhancement observed following mild stress and dysfunction following …

Adult hippocampal neurogenesis is a critical form of cellular plasticity that is greatly
influenced by neural activity. Among the neurotransmitters that are widely implicated in …

High-affinity transporters for norepinephrine (NE) and serotonin (5-HT), which ensure
neurotransmitter clearance at the synapse, are the principal targets of widely used …

Chronic stress is a key risk factor for mood disorders like depression, but the stress-induced
changes in brain circuit function and gene expression underlying depression symptoms are …

Dysfunction in noradrenergic neurotransmission has long been theorized to occur in
depressive disorders. The α2 adrenergic receptor (AR) family, as a group of key players in …

Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …

Major depressive disorder (MDD) is an emergent cause of personal and socio‐economic
burden, both for the high prevalence of the disorder and the unsatisfying response rate of …

α2A-and α2C-adrenoceptors (ARs) are the primary α2-AR subtypes involved in central
nervous system (CNS) function. These receptors are implicated in the pathophysiology of …