Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Protein knockdown using the auxin-inducible degron (AID) technology is useful to study
protein function in living cells because it induces rapid depletion, which makes it possible to …

The raison d'être of meiosis is shuffling of genetic information via Mendelian segregation
and, within individual chromosomes, by DNA crossing-over. These outcomes are enabled …

Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Structural maintenance of chromosomes (SMC) protein complexes are essential for the
spatial organization of chromosomes. Whereas cohesin and condensin organize …

The cell cycle is the series of events that take place in a cell, which drives it to divide and
produce two new daughter cells. The typical cell cycle in eukaryotes is composed of the …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …

Persistent DNA double-strand breaks (DSBs) in neurons are an early pathological hallmark
of neurodegenerative diseases including Alzheimer's disease (AD), with the potential to …