Antibodies and antibody-derived macromolecules have established themselves as the
mainstay in protein-based therapeutic molecules (biologics). Our knowledge of the structure …

The four distinct T-cell antigen receptor polypeptides (α, β, γ, δ) form two different
heterodimers (α: β and γ: δ) that are very similar to immunoglobulins in primary sequence …

Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of
great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated …

We have analysed the atomic structures of Fab and VL fragments of immunoglobulins to
determine the relationship between their amino acid sequences and the three-dimensional …

Despite 30 years of study, there is no HIV-1 vaccine and, until recently, there was little hope
for a protective immunization. Renewed optimism in this area of research comes in part from …

Glycobiology: Toward Understanding the Function of Sugars | Chemical Reviews ACS ACS
Publications C&EN CAS Find my institution Log In Chemical Reviews ACS Publications …

We have identified a novel human gene of the Ig superfamily, designated LAG-3. Expression
of this gene is undetectable in resting PBL, while it is found (a 2-kb message) in activated T …

The class I histocompatibility antigen from human cell membranes has two structural motifs:
the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin …

Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …

Anatomy of the antibody molecule - ScienceDirect Skip to main contentSkip to article Elsevier
logo Journals & Books Search RegisterSign in View PDF Download full issue Search …