A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

We summarise the evidence for medicinal uses of opioids, harms related to the extramedical
use of, and dependence on, these drugs, and a wide range of interventions used to address …

The ability to predict relapse is a major goal of drug addiction research. Clinical and
diagnostic measures are useful in this regard, but these measures do not fully and …

Background The impact of prenatal opioid exposure on brain development remains poorly
understood. Methods We conducted a prospective study of term-born infants with and …

Neuroimaging studies in substance use disorder have shown widespread impairments in
white matter (WM) microstructure suggesting demyelination and axonal damage. However …

Background: Prior research utilizing whole-brain neuroimaging techniques has identified
structural differences in gray matter in opioid-dependent individuals. However, the results …

Background: Research has demonstrated that patients with opioid use disorders (OUD;
including both opioid abuse and/or dependence) have poorer neuropsychological …

Opioid use disorder (OUD) has gained increasing publicity and interest during recent years,
with many countries describing problems of epidemic proportions with regard to opioid use …

Tract‐based spatial statistics (TBSS) of diffusion tensor imaging (DTI) studies have
consistently shown diminished white matter (WM) integrity for individuals with cocaine use …