[HTML][HTML] An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework

R Ding, X Ren, Q Sun, Z Sun, J Duan - Journal of Advanced Research, 2023 - Elsevier
Background Nowadays, cigarette smoking remains the leading cause of chronic disease
and premature death, especially cardiovascular disease. As an emerging tobacco product, e …

Pharmacological and physiological response in Apoe−/− mice exposed to cigarette smoke or e-cigarette aerosols

MJ Eden, YM Farra, J Matz, C Bellini… - Inhalation …, 2022 - Taylor & Francis
Objective Electronic cigarettes (e-cigs) are popular nicotine delivery devices, yet the health
effects remain unclear. To determine equivalent biomarkers, we characterized the …

Mapping the unicellular transcriptome of the ascending thoracic aorta to changes in mechanosensing and mechanoadaptation during aging

CF Rivera, YM Farra, M Silvestro, S Medvedovsky… - Aging …, 2024 - Wiley Online Library
Aortic stiffening is an inevitable manifestation of chronological aging, yet the mechano‐
molecular programs that orchestrate region‐and layer‐specific adaptations along the length …

[HTML][HTML] Diabetes-Related Changes in Carotid Wall Properties: Role of Triglycerides

M Kozakova, C Morizzo, G Penno, D Chiappino… - Journal of Clinical …, 2024 - mdpi.com
Background/Objectives: This study compares the power of the radiofrequency (RF) signal
reflected from the media layer (media power) of the common carotid artery (CCA) and the …

Prolonged smoldering Douglas fir smoke inhalation augments respiratory resistances, stiffens the aorta, and curbs ejection fraction in hypercholesterolemic mice

MJ Eden, J Matz, P Garg, M Perera-Gonzalez… - Science of The Total …, 2023 - Elsevier
While mounting evidence suggests that wildland fire smoke (WFS) inhalation may increase
the burden of cardiopulmonary disease, the occupational risk of repeated exposure during …

E-cigarette aerosol exposure effect on bone biomechanical properties in murine models

M Morgan, YM Farra, A Vergara-Anglim, C Bellini… - Journal of …, 2024 - Elsevier
Numerous studies have shown the detrimental health effects of tobacco smoking on bone
volume and strength in human and animal models. Little is known regarding the impacts of e …

Respiratory mechanics following chronic cigarette smoke exposure in the Apoe mouse model

J Matz, YM Farra, HM Cotto, C Bellini… - … and Modeling in …, 2023 - Springer
Even though cigarette smoking (CS) has been on the decline over the past 50 years, it is still
the leading cause of preventable premature death in the United States. Preclinical models …

[HTML][HTML] Association between tobacco smoking and heart disease in older adults: a cross-sectional study based on the Chinese Longitudinal Healthy Longevity Survey

M Liu, M Zheng, S He - Annals of Translational Medicine, 2023 - ncbi.nlm.nih.gov
Background The association between the risk of heart disease and tobacco smoking has
been studied in previous work, but there are arguments among various population. We …

[HTML][HTML] The Fbn1 gene variant governs passive ascending aortic mechanics in the mgΔlpn mouse model of Marfan syndrome when superimposed to perlecan …

SA Tarraf, RB de Souza, A Herrick… - Frontiers in …, 2024 - frontiersin.org
Introduction Ascending thoracic aortic aneurysms arise from pathological tissue remodeling
that leads to abnormal wall dilation and increases the risk of fatal dissection/rupture. Large …

[HTML][HTML] Biomechanical remodeling of the murine descending thoracic aorta during late-gestation pregnancy

AI Vargas, SA Tarraf, TP Fitzgibbons, C Bellini… - Current Research in …, 2023 - Elsevier
With the rise in maternal mortality rates and the growing body of epidemiological evidence
linking pregnancy history to maternal cardiovascular health, it is essential to comprehend …