Vitamin interdependencies predicted by metagenomics-informed network analyses and validated in microbial community microcosms

T Hessler, RJ Huddy, R Sachdeva, S Lei… - Nature …, 2023 - nature.com
Metagenomic or metabarcoding data are often used to predict microbial interactions in
complex communities, but these predictions are rarely explored experimentally. Here, we …

Synthetic microbial ecology: engineering habitats for modular consortia

YC Chen, L Destouches, A Cook… - Journal of Applied …, 2024 - academic.oup.com
Microbiomes, the complex networks of micro-organisms and the molecules through which
they interact, play a crucial role in health and ecology. Over at least the past two decades …

[HTML][HTML] Cybergenetic control of microbial community composition

TA Lee, H Steel - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
The use of bacterial communities in bioproduction instead of monocultures has potential
advantages including increased productivity through division of labour, ability to utilise …

Co-cultivation is a powerful approach to produce a robust functionally designed synthetic consortium as a live biotherapeutic product (LBP)

F Kurt, GE Leventhal, MR Spalinger, L Anthamatten… - Gut …, 2023 - Taylor & Francis
The success of fecal microbiota transplants (FMT) has provided the necessary proof-of-
concept for microbiome therapeutics. Yet, feces-based therapies have many associated …

[HTML][HTML] Competition for shared resources increases dependence on initial population size during coalescence of gut microbial communities

DA Goldman, KS Xue, AB Parrott, RR Jeeda… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The long-term success of introduced populations depends on their initial size and ability to
compete against existing residents, but it remains unclear how these factors collectively …

Artificial selection improves pollutant degradation by bacterial communities

FI Arias-Sánchez, B Vessman, A Haym, G Alberti… - bioRxiv, 2023 - biorxiv.org
Artificial selection is a promising way to improve microbial community functions, but previous
experiments have only shown moderate success. Here, we experimentally evaluate a new …

Richness and density jointly determine context dependence in bacterial interactions

KD Dooley, J Bergelson - Iscience, 2024 - cell.com
Pairwise interactions are often used to predict features of complex microbial communities
due to the challenge of measuring multi-species interactions in high dimensional contexts …

Predicting and prioritizing species coexistence: learning outcomes via experiments

B Blonder, O Godoy - bioRxiv, 2022 - biorxiv.org
Predicting species coexistence can be difficult often because underlying assembly
processes are unknown and data are limited. However, accurate predictions are needed for …

Statistical design of a synthetic microbiome that clears a multi-drug resistant gut pathogen

R Oliveira, B Pandey, K Lee, M Yousef, RY Chen… - bioRxiv, 2024 - biorxiv.org
Microbiomes perform critical functions across many environments on Earth1, 2, 3. However,
elucidating principles of their design is immensely challenging4, 5, 6, 7. Using a diverse …

Human gut microbiota interactions shape the long-term growth dynamics and evolutionary adaptations of Clostridioides difficile

JE Sulaiman, J Thompson, PLK Cheung, Y Qian, J Mill… - bioRxiv, 2024 - biorxiv.org
Clostridioides difficile can transiently or persistently colonize the human gut, posing a risk
factor for infections. This colonization is influenced by complex molecular and ecological …