Candidiasis and Mechanisms of Antifungal Resistance

S Bhattacharya, S Sae-Tia, BC Fries - Antibiotics, 2020 - mdpi.com
Candidiasis can be present as a cutaneous, mucosal or deep-seated organ infection, which
is caused by more than 20 types of Candida sp., with C. albicans being the most common …

Fungal Resistance to Echinocandins and the MDR Phenomenon in Candida glabrata

KR Healey, DS Perlin - Journal of fungi, 2018 - mdpi.com
Candida glabrata has thoroughly adapted to successfully colonize human mucosal
membranes and survive in vivo pressures. prior to and during antifungal treatment. Out of all …

Recent gene selection and drug resistance underscore clinical adaptation across Candida species

MÀ Schikora-Tamarit, T Gabaldón - Nature Microbiology, 2024 - nature.com
Understanding how microbial pathogens adapt to treatments, humans and clinical
environments is key to infer mechanisms of virulence, transmission and drug resistance …

Divergent Approaches to Virulence in C. albicans and C. glabrata: Two Sides of the Same Coin

M Galocha, P Pais, M Cavalheiro, D Pereira… - International journal of …, 2019 - mdpi.com
Candida albicans and Candida glabrata are the two most prevalent etiologic agents of
candidiasis worldwide. Although both are recognized as pathogenic, their choice of …

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species

KM Czajka, K Venkataraman, D Brabant-Kirwan… - Cells, 2023 - mdpi.com
Candidiasis is a highly pervasive infection posing major health risks, especially for
immunocompromised populations. Pathogenic Candida species have evolved intrinsic and …

Using genomics to understand the mechanisms of virulence and drug resistance in fungal pathogens

MÀ Schikora-Tamarit, T Gabaldón - Biochemical Society …, 2022 - portlandpress.com
Fungal pathogens pose an increasingly worrying threat to human health, food security and
ecosystem diversity. To tackle fungal infections and improve current diagnostic and …

Genome Comparisons of Candida glabrata Serial Clinical Isolates Reveal Patterns of Genetic Variation in Infecting Clonal Populations

L Carreté, E Ksiezopolska, E Gómez-Molero… - Frontiers in …, 2019 - frontiersin.org
Candida glabrata is an opportunistic fungal pathogen that currently ranks as the second
most common cause of candidiasis. Although the mechanisms underlying virulence and …

[HTML][HTML] Microevolution of the pathogenic yeasts Candida albicans and Candida glabrata during antifungal therapy and host infection

P Pais, M Galocha, R Viana, M Cavalheiro… - Microbial Cell, 2019 - ncbi.nlm.nih.gov
Infections by the pathogenic yeasts Candida albicans and Candida glabrata are among the
most common fungal diseases. The success of these species as human pathogens is …

[HTML][HTML] Multiple genome analysis of Candida glabrata clinical isolates renders new insights into genetic diversity and drug resistance determinants

P Pais, M Galocha, A Takahashi-Nakaguchi… - Microbial Cell, 2022 - ncbi.nlm.nih.gov
The emergence of drug resistance significantly hampers the treatment of human infections,
including those caused by fungal pathogens such as Candida species. Candida glabrata …

[HTML][HTML] Candida glabrata hospital isolate from Lebanon reveals micafungin resistance associated with increased chitin and resistance to a cell-surface-disrupting …

N Fattouh, RA Khalaf, R Husni - Journal of global antimicrobial resistance, 2024 - Elsevier
Objectives This study aimed to identify the resistance mechanisms to micafungin and
fluconazole in a clinical isolate of Candida glabrata. Methods The isolate was whole …