Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

Abstract Three-dimensional (3D) culture systems are becoming increasingly popular due to
their ability to mimic tissue-like structures more effectively than the monolayer cultures. In …

Current in vitro antitumor drug screening strategies insufficiently mimic biological systems.
They tend to lack true perfusion and draining microcirculation systems, which may post …

Chemotherapy is commonly associated with limited effectiveness and unwanted side effects
in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells …

Epithelial-to-mesenchymal transition (EMT), an evolutionary conserved phenomenon, has
been extensively studied to address the unresolved variable treatment response across …

The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …

Abstract Three-dimensional (3D) bioprinting is a novel technology that enables the creation
of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted …

Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms
of cancers. The high level of inter‐and intratumoral heterogeneity along with its biological …

The immune system provides our defense against pathogens and aberrant cells, including
tumorigenic and infected cells. Motility is one of the fundamental characteristics that enable …

Abstract The three‐dimensional (3D) cell culture model has been increasingly used to study
cancer biology and screen for anticancer agents due to its close mimicry to in vivo tumor …