Super-resolution microscopy has overcome a long-held resolution barrier—the diffraction
limit—in light microscopy and enabled visualization of previously invisible molecular details …

Single-molecule super-resolution fluorescence microscopy and single-particle tracking are
two imaging modalities that illuminate the properties of cells and materials on spatial scales …

Small RNAs are ubiquitously present regulators in all kingdoms of life. Most bacterial and
archaeal small RNAs (sRNAs) act by antisense mechanisms on multiple target mRNAs …

Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …

Highlights•Hfq contacts RNA via proximal, distal, rim and C-terminal surfaces.•RNAs interact
with Hfq in multiple ways.•Mechanisms of Hfq-facilitated RNA pairing are being elucidated …

Stochastic restart may drastically reduce the expected run time of a computer algorithm,
expedite the completion of a complex search process, or increase the turnover rate of an …

Highlights•Novel cross-linking and sequencing methods uncover new sRNAs and sRNA
networks.•Many sRNAs are encoded within the 3′ and 5′ UTRs of mRNA as well as …

Extracellular vesicles (EVs) have been the focus of great interest, as they appear to be
involved in numerous important cellular processes. They deliver bioactive macromolecules …

RNA is involved in the regulation of multiple cellular processes, often by forming sequence-
specific base pairs with cellular RNA or DNA targets that must be identified among the large …

RNA localization is highly regulated, with subcellular organization driving context-
dependent cell physiology. Although proximity-based labelling technologies that use highly …