Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention

CL Holmes, OR Albin, HLT Mobley… - Nature Reviews …, 2024 - nature.com
Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

Sphingosine 1-phosphate signaling during infection and immunity

S Mohammed, A Bindu, A Viswanathan… - Progress in Lipid …, 2023 - Elsevier
Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Fitness factor genes conserved within the multi-species core genome of Gram-negative Enterobacterales species contribute to bacteremia pathogenesis

HLT Mobley, MT Anderson, BS Moricz… - Plos …, 2024 - journals.plos.org
There is a critical gap in knowledge about how Gram-negative bacterial pathogens, using
survival strategies developed for other niches, cause lethal bacteremia. Facultative …

99mTc-Labeled, Colistin Encapsulated, Theranostic Liposomes for Pseudomonas aeruginosa Infection

M Karpuz, A Temel, E Ozgenc, Y Tekintas… - AAPS …, 2023 - Springer
Infectious diseases are still the major issue not only due to antibiotic resistance but also
causing deaths if not diagnosed at early-stages. Different approaches including nanosized …

Modified N-acyl-L-homoserine lactone compounds abrogate Las-dependent quorum-sensing response in human pathogen Pseudomonas aeruginosa

F Ballante, MV Turkina, M Ntzouni… - Frontiers in Molecular …, 2023 - frontiersin.org
Quorum sensing (QS) is a mode of cell–cell communication that bacteria use to sense
population density and orchestrate collective behaviors. The common opportunistic human …

Novel broadly reactive monoclonal antibody protects against Pseudomonas aeruginosa infection

M Mateu-Borrás, SR Dublin, J Kang… - Infection and …, 2024 - journals.asm.org
The incidence of infections attributed to antimicrobial-resistant (AMR) pathogens has
increased exponentially over the recent decades reaching 1.27 million deaths worldwide in …

Synthesis of biocomposites from microalgal peptide incorporated polycaprolactone/κ-carrageenan nanofibers and their antibacterial and wound healing property

S Raghunathan, S Kandasamy, AB Pillai… - International Journal of …, 2024 - Elsevier
Antimicrobial peptides (AMPs) are promising novel agents for targeting a wide range of
pathogens. In this study, microalgal peptides derived from native microalgae were …

Cleavage of cell junction proteins as a host invasion strategy in leptospirosis

P Kumari, S Yadav, S Sarkar… - Applied Microbiology and …, 2024 - Springer
Infection and invasion are the prerequisites for developing the disease symptoms in a host.
While the probable mechanism of host invasion and pathogenesis is known in many …

Impatto della Terapia Empirica Adeguata di Combinazione sulla Mortalità in Pazienti con Shock Settico secondario a Batteriemia da Pseudomonas aeruginosa: studio …

M Schenone - 2024 - unire.unige.it
Obiettivo: Determinare l'impatto di una terapia empirica adeguata di combinazione sulla
mortalità per ciascuna causa a 30 giorni, in pazienti con shock settico dovuto a batteriemia …

The Role of the ArcA Metabolic Regulator in Gram-Negative Bacteremia

A Brown - 2023 - deepblue.lib.umich.edu
Infections of the bloodstream are life-threatening and can result in sepsis. Gram-negative
bacteria cause a significant portion of bloodstream infections, which is also referred to as …