Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Non-alcoholic fatty liver disease (NAFLD) is highly prevalent among individuals with type 2
diabetes. Although epidemiological studies have shown that NAFLD is associated with …

Sulfoximines have been largely disregarded in medicinal chemistry for a long time.
However, recently, they have risen to the apparent level of stardom on the drug discovery …

Genotype-phenotype associations for common diseases are often compounded by
pleiotropy and metabolic state. Here, we devised a pooled human organoid-panel of …

Cachexia is a wasting disorder that accompanies many chronic diseases including cancer
and results from an imbalance of energy requirements and energy uptake. In cancer …

Obesity and type 2 diabetes mellitus (T2DM) are the leading worldwide risk factors for
mortality. The inextricably interlinked pathological progression from excessive weight gain …

The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes
hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with …

Type 2 diabetes mellitus is a metabolic disorder with complicated pathogenesis, and mono-
target therapy often fails to effectively manage the levels of blood glucose. In recent years …

Insulin integrates hepatic glucose and lipid metabolism, directing nutrients to storage as
glycogen and triglyceride. In type 2 diabetes, levels of the former are low and the latter are …

Glucose metabolism in humans is tightly controlled by the activity of glucokinase (GCK).
GCK is predominantly produced in the pancreas, where it catalyzes the rate-limiting step of …