SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responses

R Tomecki, K Drazkowska… - Wiley Interdisciplinary …, 2023 - Wiley Online Library
RNA stability and quality control are integral parts of gene expression regulation. A key
factor shaping eukaryotic transcriptomes, mainly via 3′–5′ exoribonucleolytic trimming or …

The interplay between the RNA decay and translation machinery in eukaryotes

AM Heck, J Wilusz - Cold Spring Harbor Perspectives in …, 2018 - cshperspectives.cshlp.org
RNA decay plays a major role in regulating gene expression and is tightly networked with
other aspects of gene expression to effectively coordinate post-transcriptional regulation …

mRNA levels can be reduced by antisense oligonucleotides via no-go decay pathway

X Liang, JG Nichols, CW Hsu, TA Vickers… - Nucleic Acids …, 2019 - academic.oup.com
Antisense technology can reduce gene expression via the RNase H1 or RISC pathways and
can increase gene expression through modulation of splicing or translation. Here, we …

Attacked from all sides: RNA decay in antiviral defense

JM Molleston, S Cherry - Viruses, 2017 - mdpi.com
The innate immune system has evolved a number of sensors that recognize viral RNA
(vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that …

Functions of unconventional mammalian translational GTPases GTPBP1 and GTPBP2

A Zinoviev, A Goyal, S Jindal, J LaCava… - Genes & …, 2018 - genesdev.cshlp.org
Abstract GTP-binding protein 1 (GTPBP1) and GTPBP2 comprise a divergent group of
translational GTPases with obscure functions, which are most closely related to eEF1A …

ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay

KA Limoncelli, CN Merrikh, MJ Moore - Rna, 2017 - rnajournal.cshlp.org
In budding yeast, inactivating mutations within the 40S ribosomal subunit decoding center
lead to 18S rRNA clearance by a quality control mechanism known as nonfunctional 18S …

Processing body (P-body) and its mediators in cancer

B Nsengimana, FA Khan, EE Ngowi, X Zhou… - Molecular and cellular …, 2022 - Springer
In recent years, processing bodies (P-bodies) formed by liquid–liquid phase separation,
have attracted growing scientific attention due to their involvement in numerous cellular …

Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition

LE Cabrera-Quio, A Schleiffer, K Mechtler… - PLoS Genetics, 2021 - journals.plos.org
Post-transcriptional regulation of gene expression is crucial during the oocyte-to-embryo
transition, a highly dynamic process characterized by the absence of nuclear transcription …

A two-headed monster to avert disaster: HBS1/SKI7 is alternatively spliced to build eukaryotic RNA surveillance complexes

JO Brunkard, B Baker - Frontiers in plant science, 2018 - frontiersin.org
The cytosolic RNA exosome, a 3′→ 5′ exoribonuclease complex, contributes to mRNA
degradation in eukaryotes, limiting the accumulation of poorly-translated, improperly …

Misdecoding of rare CGA codon by translation termination factors, eRF1/eRF3, suggests novel class of ribosome rescue pathway in S. cerevisiae

M Wada, K Ito - The FEBS Journal, 2019 - Wiley Online Library
The CGA arginine codon is a rare codon in Saccharomyces cerevisiae. Thus, full‐length
mature protein synthesis from reporter genes with internal CGA codon repeats are markedly …