Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

3', 5'-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …

In the last 30 years, the field of cyclic adenosine 3′, 5′-monophosphate (cAMP) signalling
has witnessed a transformative development with the realization that cAMP is …

The Popeye domain containing (POPDC) genes encode sarcolemma-localized cAMP
effector proteins. Mutations in blood vessel epicardial substance (BVES) also known as …

The development of a wider range of therapeutic options is a key objective in drug discovery
for chronic obstructive pulmonary disease (COPD). Fundamental advances in lung biology …

Biological processes incorporate feedback mechanisms to enable positive and/or negative
regulation. cAMP is an important second messenger involved in many aspects of muscle …

Abstract Increased concentrations of lactate (15–30 mM) are associated with and found to
be neuroprotective in various brain pathophysiology. In our earlier studies we showed that …

Popeye domain containing (POPDC) proteins are predominantly expressed in the heart and
skeletal muscle, modulating the K 2P potassium channel TREK-1 in a cAMP-dependent …

Human transmembrane adenylyl cyclase 9 (AC9) is not regulated by heterotrimeric G
proteins. Key to the resistance to stimulation by Gs-coupled receptors (GsRs) is auto …

The Popeye domain‐containing protein 3 (POPDC3), a transmembrane protein with a
unique cyclic adenosine monophosphate (cAMP) binding site, is widely expressed in …